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Rahim et al. show that immune checkpoint blockade activates CD8 T cell differentiation and proliferation in the lymph node, not within the tumor microenvironment, and these cells can be detected in transit via blood profiling.
CD4+ T cells in cancer
Dynamic CD8+ T cell responses to cancer immunotherapy in human regional lymph nodes are disrupted in metastatic lymph nodes - ScienceDirect
// Powered by Mass Cytometry - Dynamic CD8+ T cell responses to cancer immunotherapy in human regional lymph nodes are disrupted in metastatic lymph nodes
Cancers, Free Full-Text
The history and advances in cancer immunotherapy: understanding the characteristics of tumor-infiltrating immune cells and their therapeutic implications
LPA suppresses T cell function by altering the cytoskeleton and disrupting immune synapse formation
Population of CD4 + and CD8 + cells in mesenteric lymph node during
Frontiers Therapeutic Implications of Tumor Microenvironment in Lung Cancer: Focus on Immune Checkpoint Blockade
Quality of CD8+ T cell immunity evoked in lymph nodes is compartmentalized by route of antigen transport and functional in tumor context
Cancers, Free Full-Text
Cells, Free Full-Text
Melanoma-derived mediators can foster the premetastatic niche: crossroad to lymphatic metastasis: Trends in Immunology
Dynamic CD8+ T cell responses to cancer immunotherapy in human regional lymph nodes are disrupted in metastatic lymph nodes - ScienceDirect
Cisplatin Nanoparticles Promote Intratumoral CD8+ T Cell Priming via Antigen Presentation and T Cell Receptor Crosstalk