Glutamine, the most abundant free amino acid in the human body, is a major substrate utilized by intestinal cells. The roles of glutamine in intestinal physiology and management of multiple intestinal diseases have been reported. In gut physiology, glutamine promotes enterocyte proliferation, regulates tight junction proteins, suppresses pro-inflammatory signaling pathways, and protects cells against apoptosis and cellular stresses during normal and pathologic conditions. As glutamine stores are depleted during severe metabolic stress including trauma, sepsis, and inflammatory bowel diseases, glutamine supplementation has been examined in patients to improve their clinical outcomes. In this review, we discuss the physiological roles of glutamine for intestinal health and its underlying mechanisms. In addition, we discuss the current evidence for the efficacy of glutamine supplementation in intestinal diseases.
IJMS, Free Full-Text
International Journal of Molecular Medicine
IJMS, Free Full-Text, test vivo
IJMS, Free Full-Text, bronstein meier ii
Ijms Free Full Text Quantification And Application Of Potential Epigenetic Markers In
Pat Testing Labels Template Unique Ijms Free Full Text Genome Editing In Agriculture - Best Templates Ideas, Best Tem…
IJMS, Free Full-Text, wca live bot
IJMS, Free Full-Text
IJMS, Free Full-Text, bronstein meier ii
Value LeaderIJMS, Free Full-Text, your channel
ISSN 1422-0067 (Online), International journal of molecular sciences
IJMS, Free Full-Text, niemann pick tipo c
IJMS, Free Full-Text, evades el tema
IJMS, Free Full-Text, niemann pick tipo c
IJMS, Free Full-Text
