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Limited drainage tunnels face pore water pressure, water inflow, and permeability challenges. At present, there is little systematic analysis and research on the lining water pressure of sub-sea tunnels, and there is a lack of verification of relevant engineering examples and field monitoring data. Based on the numerical simulation method, this paper discusses the lining water pressure and its reduction coefficient of the horseshoe section tunnel, which is verified by an engineering example. Based on many numerical simulations, the recommended value of the water pressure reduction coefficient considering the thickness of the grouting ring and grouting effect is put forward. The stress law and safety of tunnel lining under different water reduction coefficients are studied, and the safety of lining is evaluated combined with the measured data of lining stress. The results show that the numerical simulation has been well verified. Considering the water pressure according to the water pressure reduction coefficient method proposed in this paper can ensure the structural safety of tunnel lining. The method of lining water pressure reduction coefficient proposed in this paper can provide a reference for the subsequent lining design of the sub-sea tunnel.